Protamine induces vasorelaxation of human internal thoracic artery by endothelial NO- synthase pathway Dmitry Pevni, MD, Jacob Gurevich, MD, Inna Frolkis,

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Presentation transcript:

Protamine induces vasorelaxation of human internal thoracic artery by endothelial NO- synthase pathway Dmitry Pevni, MD, Jacob Gurevich, MD, Inna Frolkis, MD, PhD, Gad Keren, MD, Izhak Shapira, MD, Josef Paz, MD, Amir Kramer, MD, Chaim Locker, MD, Rephael Mohr, MD The Annals of Thoracic Surgery Volume 70, Issue 6, Pages 2050-2053 (December 2000) DOI: 10.1016/S0003-4975(00)01678-7

Fig 1 Original traces showing the effect of protamine on precontracted human internal thoracic artery rings. The protamine caused dose-dependent relaxation of the ring (curve A). Protamine caused a slight relaxing effect (curve B) when the NOS inhibitor L-NAM was added. Protamine concentration: 1 to 50 μg/ml, 2 to 100 μg/ml, 3 to 200 μg/ml, and so on, to 9 to 800 μg/ml. The Annals of Thoracic Surgery 2000 70, 2050-2053DOI: (10.1016/S0003-4975(00)01678-7)

Fig 2 Relaxation induced by protamine sulfate in precontacted human internal thoracic artery rings with and without the NOS inhibitor, L-NAM. The Annals of Thoracic Surgery 2000 70, 2050-2053DOI: (10.1016/S0003-4975(00)01678-7)

Fig 3 Relaxation induced by protamine sulfate in precontracted human internal thoracic artery rings with and without aminoguanidine. The Annals of Thoracic Surgery 2000 70, 2050-2053DOI: (10.1016/S0003-4975(00)01678-7)

Fig 4 Relaxation induced by protamine sulfate in precontracted human internal thoracic artery rings with and without heparin. The Annals of Thoracic Surgery 2000 70, 2050-2053DOI: (10.1016/S0003-4975(00)01678-7)