GR CAFs modulate the EGFR-TKI response in cocultured tumor cells.

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Presentation transcript:

GR CAFs modulate the EGFR-TKI response in cocultured tumor cells. GR CAFs modulate the EGFR-TKI response in cocultured tumor cells. A and B, immunoblots for pEGFR, pMAPK, and pAkt in GP epithelial tumor cells (A) and HCC827 cells (B) showing the effect of gefitinib treatment upon coculture with GP or GR CAFs. Densitometric intensities for each marker were determined, and the marker that shows the most dramatic modification in each cell type in presence of gefitinib is presented. Sheldon R. Mink et al. Mol Cancer Res 2010;8:809-820 ©2010 by American Association for Cancer Research