A “Fille du Roy” Introduced the T14484C Leber Hereditary Optic Neuropathy Mutation in French Canadians Anne-Marie Laberge, Michèle Jomphe, Louis Houde,

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A “Fille du Roy” Introduced the T14484C Leber Hereditary Optic Neuropathy Mutation in French Canadians Anne-Marie Laberge, Michèle Jomphe, Louis Houde, Hélène Vézina, Marc Tremblay, Bertrand Desjardins, Damian Labuda, Marc St- Hilaire, Carol Macmillan, Eric A. Shoubridge, Bernard Brais The American Journal of Human Genetics Volume 77, Issue 2, Pages 313-317 (August 2005) DOI: 10.1086/432491 Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigree of the 11 probands sharing the same female ancestor and their relationship with the family reported in 1970 (Brunette and Bernier 1970). The American Journal of Human Genetics 2005 77, 313-317DOI: (10.1086/432491) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 2 Geographic distribution of the marriage parishes of the single female ancestor’s female descendants, by generation (1669–1800) (A and B) and geographic distribution of current cases that are due to T14484C mutation (C). An asterisk (*) marks the 5th generation, which is incomplete, because data are available only through 1800. The American Journal of Human Genetics 2005 77, 313-317DOI: (10.1086/432491) Copyright © 2005 The American Society of Human Genetics Terms and Conditions