Depressed Mood Disorders and Disturbances ≤3.1%

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Presentation transcript:

Depressed Mood Disorders and Disturbances ≤3.1% Varenicline Bupropion Placebo Incidence (%) 95% CI DMDD, all 2.8 2.2-3.5 3.1 2.0-4.6 1.8 1.2-2.6 DMDD, drug-related 1.2 – 2.3 1.1

Psychiatric AEs >1% Psychiatric Adverse Events Varenicline Bupropion Placebo Incidence (%) 95% CI Anxiety disorders and symptoms 4.6 3.8, 5.5 8.3 6.5, 10.4 5.1 4.1, 6.3 Changes in physical activity (bruxism, restlessness) 1.1 0.7, 1.6 2.0 1.2, 3.2 1.0 0.6, 1.6 Mood disorders and disturbances 2.3 1.8, 3.0 1.6 1.1, 2.4