Aliskiren, the orally effective renin inhibitor, provides antihypertensive efficacy at least equivalent to the ARB irbesartan in patients with hypertension.

Slides:

Advertisements

Similar presentations

CR-1 ATACAND ® (candesartan cilexetil) Cardiovascular and Renal Drugs Advisory Committee Bethesda, Maryland July 18, 2002 C.

Advertisements

Pharmacology DOR 101 Abdelkader Ashour, Ph.D. 9 th Lecture.

Hypertension Diagnosis and Treatment  Based on JNC 7 – published in 2003  Goal: BP

New concept – no traditional combination LODOZ contains Bisoprolol and Hydrochlorothiazide in subtherapeutic dosages: - Bisoprolol 2.5 mg (= half / quarter.

Aim To determine the effects of a Coversyl- based blood pressure lowering regimen on the risk of recurrent stroke among patients with a history of stroke.

A Global Perspective on Blood Pressure Treatment and Control in a Referred Cohort of Hypertensive Patients Bramlage P, et al. J Clin Hyper. doi: /j x.

Objective: To asses the efficacy of hydrochlorothiazide on 24-h blood pressure (BP) control.Methods: Review of all the randomized trials that assessed.

Empagliflozin Reduces Blood Pressure in Patients With Type 2 Diabetes and Hypertension Featured Article: Ilkka Tikkanen, Kirsi Narko, Cordula Zeller, Alexandra.

Relationship of background ACEI dose to benefits of candesartan in the CHARM-Added trial.

Date of download: 5/29/2016 Copyright © The American College of Cardiology. All rights reserved. From: Renal Denervation in Moderate Treatment-Resistant.

Copyright © 2003 American Medical Association. All rights reserved.

Baseline characteristics and effectiveness results

Neal B, et al. Diabetes Care 2015;38:403–411

Aliskiren and Valsartan for Antihypertensive Therapy Trial

Dolutegravir versus Raltegravir in Treatment Experienced SAILING Study

Mean 24-Hour, Daytime, and Night Ambulatory Systolic BP, Diastolic BP, and PP Before (Week 0) and After (Week 12) NAG and Placebo Intake in 37 Hypertensive.

Copyright © 2007 American Medical Association. All rights reserved.

Attenuation of the “White-Coat Effect” by Antihypertensive Treatment and Regression of Target Organ Damage by Gianfranco Parati, Luisa Ulian, Lorena Sampieri,

Compared with irbesartan, there was a greater reduction in UP/C with sparsentan, and a larger proportion of patients achieved FPRE. The figure illustrates.

Patient disposition for the double-blind study period.

AARDVARK Trial design: Patients with small abdominal aortic aneuryms (AAAs) were randomized in a 1:1:1 fashion to either perindopril 10 mg once daily,

Nat. Rev. Nephrol. doi: /nrneph

Asthma diagnosis and treatment: Filling in the information gaps

Volume 93, Issue 1, Pages (January 2018)

Figure 1 Changes in relative plasma volume (RPV)

Safety of Celecoxib in Patients With Ulcerative Colitis in Remission: A Randomized, Placebo-Controlled, Pilot Study William J. Sandborn, William F. Stenson,

Elke Wühl, Otto Mehls, Franz Schaefer Kidney International

Patient disposition. Patient disposition. AE, adverse event. *One patient died during the follow-up period. ^Four of the 12 discontinuations of treatment.

Valentina Forni, Gregoire Wuerzner, Menno Pruijm, Michel Burnier

Volume 67, Pages S52-S54 (January 2005)

Incidence of in-hospital mortality rates are lower in rapid correction rate group versus slow correction rate group but not significantly different by.

Thirty-day survival curves for the rapid versus slow correction rate groups are not significantly different. Thirty-day survival curves for the rapid versus.

Volume 54, Pages S135-S139 (December 1998)

Importance of blood pressure control in hemodialysis patient survival

Mean and median systolic and diastolic BPs after dialysis were unchanged over time and similar between epoetin alfa-epbx and epoetin alfa. Mean and median.

Lifestyle intervention was associated with improved cardiorespiratory fitness. Lifestyle intervention was associated with improved cardiorespiratory fitness.

Volume 68, Issue 3, Pages (September 2005)

Ionized-to-total magnesium (Mg) and calcium (Ca) ratios are lower in patients on hemodialysis than those in patients not on dialysis. Ionized-to-total.

Dialyzer clearance of ampicillin/sulbactam in plasma of critically ill patients with AKI undergoing extended dialysis. Dialyzer clearance of ampicillin/sulbactam.

This comparative clinical trial of IV epoetin alfa-epbx versus epoetin alfa was a randomized, active-controlled, parallel-group, double-blind study including.

(A) Distribution of CsA nephrotoxicity lesions according to antihypertensive treatment and CsA C2 levels. (A) Distribution of CsA nephrotoxicity lesions.

Unadjusted odds ratio of death at 6 mo for medications (β blockers [BBL], angiotensin-converting enzyme inhibitors [ACEI]/angiotensin receptor blockers.

The development of regional ventricular dysfunction as measured by regional wall motion abnormalities (RWMA; abnormal regions) was associated with a greater.

Cardiac index (CI) changes from baseline following single oral doses of riociguat (○) 1 mg and 2.5 mg compared with inhaled nitric oxide (•) in patients.

Clinical characteristics and laboratory parameters in relation to dose of oral sodium bicarbonate. Clinical characteristics and laboratory parameters in.

Volume 73, Issue 11, Pages (June 2008)

Serum bicarbonate increased by ≥3, ≥4, and ≥5 mEq/L in 52%, 39%, and 22% of patients, respectively, in the combined TRC101 dose group compared with 6%,

Graph showing percentage of total patients with PTD or IGT that would be detected in each category of FBG if an oral glucose tolerance test were performed.

Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal.

Six-month change in proteinuria predicts risk for ESRD

Combination angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) reduced risk for renal end point versus ACEI or ARB. Effect.

Distribution of percent consistent facility aspirin use.

Changes in 44-hour interdialytic systolic BP as a function of change in echocardiographic volume parameter. Changes in 44-hour interdialytic systolic BP.

Effects of placebo or carvedilol CR on 24-hour mean systolic blood pressure and diastolic blood pressure obtained by ambulatory monitoring in hypertensive.

Pharmacokinetics and pharmacodynamics of diuretic action.

Apremilast, an oral phosphodiesterase-4 inhibitor, in the treatment of palmoplantar psoriasis: Results of a pooled analysis from phase II PSOR-005 and.

Per dialysis treatment funding and facility/network staff ratio by ESRD Network. Per dialysis treatment funding and facility/network staff ratio by ESRD.

Role of - Azilsartan - Azilsartan/chlorthalidone

A total of 150 dialysis patients washed out of previous antihypertensive therapy (Pretreatment) and underwent periodic evaluation of aortic PWV (line indicating.

Change in coronary artery calcification in patients who were treated with calcium or sevelamer. Change in coronary artery calcification in patients who.

Changes in urinary albumin excretion rate in relation to baseline (top), cross-sectional values of GFR (middle), and MABP (bottom) during treatment with.

Prevalence of primary aldosteronism in patients according to Sixth Joint National Committee (JNC VI) stages of severity of hypertension (stage 1, 140 to.

Study design. aPatients initially receiving tenapanor 30 mg twice a day were allowed to down-titrate weekly (stepwise 30 → 20 → 15 → 10 → 3 mg twice a.

Study protocol. Study protocol. All participants were studied on four occasions: Twice before and twice after an 8-wk treatment period on low-dosage, low.

Mean number of dialysis sessions per patient for which intradialytic hypotension–related nursing interventions were required during the first 2 wk and.

Cardiac index (CI) changes from baseline following single oral doses of riociguat (Rio) compared with inhaled nitric oxide (NO) in patients with chronic.

Effect of aspirin (ASA) on serum cytokine concentration in hemodialysis (HD) patients. Effect of aspirin (ASA) on serum cytokine concentration in hemodialysis.

Data normalization process.

Distribution of facility mean treatment time, by DOPPS region and phase. Distribution of facility mean treatment time, by DOPPS region and phase. Restricted.

Presentation transcript:

Aliskiren, the orally effective renin inhibitor, provides antihypertensive efficacy at least equivalent to the ARB irbesartan in patients with hypertension. Aliskiren, the orally effective renin inhibitor, provides antihypertensive efficacy at least equivalent to the ARB irbesartan in patients with hypertension. Bars indicate placebo-corrected reductions from baseline in mean sitting diastolic BP (DBP) after once-daily treatment for 8 wk with either aliskiren (▪) or irbesartan (▒). *P < 0.05 versus irbesartan 150 mg. Reproduced from reference (43) with permission. Dominik N. Müller, and Friedrich C. Luft CJASN 2006;1:221-228 ©2006 by American Society of Nephrology