A “datathon” model to support cross-disciplinary collaboration

Slides:



Advertisements
Similar presentations
Fig. 1. Map showing the study catchment area in the East of England.
Advertisements

Fig. 4. The effect of single-dose rozanolixizumab on the concentration of IgG subtypes in healthy subjects. The effect of single-dose rozanolixizumab on.
Fig. 6 Transmissibility of adiposity from humanized mice to germ-free recipients. Transmissibility of adiposity from humanized mice to germ-free recipients.
Fig. 7 Correlation of NHP and human ISGs.
Fig. 1 Movement percepts for all participants.
Fig. 4. Peanut-specific TH2A cells are specifically targeted during immunotherapy. Peanut-specific TH2A cells are specifically targeted during immunotherapy.
Consolidated Standards of Reporting Trials flow diagram of VRC trial
Fig. 2. Clinically actionable somatic genomic alterations in various tumor types. Clinically actionable somatic genomic alterations in various tumor types.
Filipin staining of marginal gyrus of cerebral cortex in NPC cats
Fig. 5. Microarray analysis of tumors treated by dabrafenib, trametinib, or the combination of dabrafenib and trametinib with pmel-1 ACT or mock ACT. Microarray.
Fig. 1. Schematic showing the shedding of tumor DNA from head and neck cancers into the saliva or plasma. Schematic showing the shedding of tumor DNA from.
Fig. 3. Comparison of prediction performance.
Fig. 7 Bacterial dependency networks in IgA deficiency and HDs.
Fig. 1. Animal instincts. Animal instincts. Half-horse, half-human, the mythological centaur Chiron (root, chirourgos: surgeon) taught all of the great.
Fig. 6. TIV-09, but not MIV-09, induces an IFN signature in the blood of vaccinated individuals at day 1. TIV-09, but not MIV-09, induces an IFN signature.
Fig. 3 ROC curves of mCCNA1 and mVIM assayed in esophageal cytology brushings from control normal-appearing GE junctions versus BE and EAC cases. ROC curves.
Fig. 2 Preserved long-term functionality of the TEHVs over 1-year follow-up as assessed by ICE and cardiac MRI flow measurements. Preserved long-term functionality.
Fig. 3 Liver stiffness and NT-proBNP concentration after treatment with miridesap followed by dezamizumab. Liver stiffness and NT-proBNP concentration.
In vivo release of doxycycline hyclate from the GRS in a swine model
Fig. 2 Fabrication and in vitro release of TB antibiotics from individual drug pills. Fabrication and in vitro release of TB antibiotics from individual.
Fig. 5. In vivo characterization of adipogenesis by CT.
Fig. 1. Value proposition. Value proposition.Summarized are the valuation estimates (log scale), from panel members (selected by A.W.L.) for the NCATS.
Fig. 2 TRXSS data. TRXSS data. TRXSS data covering delay times from 10 ns to 10 ms for wild-type DmCry (A), for the DmCry(H378A) mutant (B), and for XlPho.
Fig. 2. Bacterial/viral score in COCONUT-conormalized whole-blood validation data sets. Bacterial/viral score in COCONUT-conormalized whole-blood validation.
Fig. 5. Col IV–Ac2-26 NPs decrease lesion area, necrotic area, and oxidative stress in brachiocephalic arterial plaques. Col IV–Ac2-26 NPs decrease lesion.
Colonization in tumor models and different modes of administration
Fig. 5. Vitamin B12 supplementation in the host altered the transcriptome of P. acnes in the skin microbiota. Vitamin B12 supplementation in the host altered.
Fig. 4 Device accuracy results (n = 32 users).
Fig. 1 Inbred mouse strains carrying monoclonal tumors display a symmetrical yet disparate response to ICB, associated with a distinctive gene signature.
Fig. 3 BMS blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS blocks functional responses in primary immune.
BMS blocks functional responses in primary immune cells driven by IFNα
Fig. 1. Detection of circulating tumor DNA in CRPC patients.
Kenneth J. Ottenbacher, PhD, OTR, James E. Graham, PhD, DC 
The microchip-based drug delivery device and overview of study design
Fig. 5. Octet BLI competition assay using D25 and motavizumab.
Fig. 1 From conventional cuff-based blood pressure measurement to cuff-less BP monitoring using a smartphone. From conventional cuff-based blood pressure.
Opening Up to Precompetitive Collaboration
Technological framework of the multidirectional gravity-assist
Fig. 2 PK dosing results. PK dosing results. (A) Plasma concentration of hPTH(1–34) versus time after release of 40-μg dose from implanted microchip device.
Fig. 3 Local Maraba treatment of TNBC tumors provides long-term systemic protection. Local Maraba treatment of TNBC tumors provides long-term systemic.
A Role for Science Investments in Advancing Newborn Health
Fig. 1 Cross-sectional images of He-implanted V/Cu/V samples.
Transforming medicine with the microbiome
Fig. 1 Crohn’s disease association within the LRRK2 locus.
Fig. 2 Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes in cognition. Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes.
Fig. 8. Purkinje cell quantification and hearing threshold in NPC cats administered IC HPβCD. Purkinje cell quantification and hearing threshold in NPC.
Fig. 5. Vascularization of human liver seed grafts.
Fig. 2. Overexpression of miR cluster in the developing heart results in increased cardiomyocyte proliferation and cardiomegaly. Overexpression.
by Peter Bacchetti, Steven G. Deeks, and Joseph M. McCune
Schematic of the proposed brain-controlled assistive hearing device
Fig. 3 FTIR spectra of plastic standards and sediment samples.
Delineating cancer evolution with single-cell sequencing
Bio-AMS enhances the activity of rifampicin and ethambutol in vitro
Fig. 1. Dysbiosis of the skin microbiome in AD is associated with S
Fig. 5. High burdens of AA signature mutations and predicted immunogenicity in Taiwan HCCs. High burdens of AA signature mutations and predicted immunogenicity.
Making Prospective Registration of Observational Research a Reality
Experimenter gender and replicability in science
Fig. 3. miR overexpression leads to increased cell proliferation as well as altered differentiation and metabolism in cardiomyocytes. miR
Fig. 5 Clustering of the distal gut microbiome, the C
Fig. 1. Forecasting the future.
Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.
Fig. 3. Association between peak CTL019 expansion and response.
Fig. 1. Schematic description of whole-exome or targeted next-generation sequencing analyses. Schematic description of whole-exome or targeted next-generation.
Fig. 7. Nanowarming maintains biomechanical properties of porcine carotid arteries. Nanowarming maintains biomechanical properties of porcine carotid arteries.
Fig. 1 Isopropanol tolerance variation among E. faecium isolates.
Fig. 4 Gallium increases P. aeruginosa sensitivity to peroxides.
Fig. 8 Immune correlates of protection.
Fig. 3 Postnatal assembly of the humanized gut microbiota.
Fig. 6. Connectivity and mobility maps for Lesotho.
Fig. 1. Maps of Lesotho, a landlocked country within South Africa.
Presentation transcript:

A “datathon” model to support cross-disciplinary collaboration by Jerôme Aboab, Leo Anthony Celi, Peter Charlton, Mengling Feng, Mohammad Ghassemi, Dominic C. Marshall, Louis Mayaud, Tristan Naumann, Ned McCague, Kenneth E. Paik, Tom J. Pollard, Matthieu Resche-Rigon, Justin D. Salciccioli, and David J. Stone Sci Transl Med Volume 8(333):333ps8-333ps8 April 6, 2016 Copyright © 2016, American Association for the Advancement of Science

Fig. 1. Sample snapshots. Sample snapshots. Shown are screen shots of the Jupyter Notebooks used in the Second International Critical Care datathon to facilitate sharing of queries and codes among the teams. (A) A custom Python package was developed to assist with transforming and analyzing data. (B) Notebooks simplified data exploration. (C) Data visualization. Jerôme Aboab et al., Sci Transl Med 2016;8:333ps8 Copyright © 2016, American Association for the Advancement of Science