Schematic diagram illustrating the proposed mechanism by which Axin may interfere with normal mammary gland development in DDTg mice. Schematic diagram.

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Schematic diagram illustrating the proposed mechanism by which Axin may interfere with normal mammary gland development in DDTg mice. Schematic diagram illustrating the proposed mechanism by which Axin may interfere with normal mammary gland development in DDTg mice. Side branching, which requires Wnt-4, is not significantly affected by overexpression of Axin. However, lobulo-alveolar development is severely impaired. This may be due to the reduced expression of cyclin D1, a Wnt target gene, which is required for lobulo-alveolar development. See text for references. Diagram modified from Robinson et al. (2000). Wei Hsu et al. J Cell Biol 2001;155:1055-1064 © 2001 Rockefeller University Press