Activation of Ccl2–Ccr2 pathway is required for mammary carcinogenesis induced by Rb deficiency. Activation of Ccl2–Ccr2 pathway is required for mammary.

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Activation of Ccl2–Ccr2 pathway is required for mammary carcinogenesis induced by Rb deficiency. Activation of Ccl2–Ccr2 pathway is required for mammary carcinogenesis induced by Rb deficiency. A, IHC analysis of the indicated protein in MMTV-Cre; Rbf/f; Ccr2 WT or KO, or C57BL/6 (WT) mammary glands (>400 days). Scale bar, 50 μm. PCNA-positive cells in mammary glands were quantified (n > 3). Insets show higher magnification of mammary gland. B, Representative pictures of whole-mount carmine alum staining of MMTV-Cre; Rbf/f; Ccr2 WT or KO, or C57BL/6 (WT) mammary glands (> 400 days). Scale bar, 5 mm (left), 500 μm (middle), and 100 μm (right). LN, lymph node. C, IHC analysis of the indicated protein in MMTV-Cre; Rbf/f; Ccr2 WT or KO, or C57BL/6 (WT) mammary glands (>400 days). Scale bar, 50 μm. CCL2-positive area in mammary glands was quantified (n > 7). Insets show higher magnification of mammary gland. D, Immunofluorescence analysis of the indicated protein in MMTV-Cre; Rbf/f; Ccr2 WT or KO, or C57BL/6 (WT) mammary glands (>400 days). Scale bar, 50 μm. F4/80+ cells in mammary glands were quantified (n > 3). Insets show higher magnification of mammary gland. n.s., not significant; **, P < 0.01. Fengkai Li et al. Cancer Res 2019;79:3903-3915 ©2019 by American Association for Cancer Research