Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. Endogenously produced n-3 PUFAs inhibit endometrial cancer.

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Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. HEC-1-A (A), HEC-1-B (B) and RL95-2 cells (C) plated in 24-well plates were transfected with recombinant adenovirus with (fat-1) or without (Con) the fat-1 gene and total viable cells were counted at indicated times. *, P < 0.05, compared with respective controls. HEC-1-A (D), HEC-1-B (E), and RL95-2 cells (F) in 6-well plates were transfected with recombinant adenovirus with or without the fat-1 gene and subjected to the colony formation assay. G, fat-1/SCID or wild-type (WT) SCID mice (n = 6) were injected with a suspension of RL95-2 cells. The tumor growth curve and a comparison of average tumor weight on the final day between the two groups are shown (H). Bars, mean ± SD for three independent experiments. *, P = 0.00 compared with respective controls. Hang Zheng et al. Cancer Prev Res 2014;7:824-834 ©2014 by American Association for Cancer Research