Induction of apoptosis in human embryonic kidney 293 cells injected with phMSH2 or phMLH1 cDNA expression constructs. Induction of apoptosis in human embryonic.

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Induction of apoptosis in human embryonic kidney 293 cells injected with phMSH2 or phMLH1 cDNA expression constructs. Induction of apoptosis in human embryonic kidney 293 cells injected with phMSH2 or phMLH1 cDNA expression constructs. Left, cells expressing GFP. Right, the same fields of cells assayed by TUNEL. Cells coinjected with phMSH2 and pGFP or phMLH1 and pGFP demonstrate a high frequency of TUNEL staining. Cells coinjected with phPMS2 and pGFP do not correspond with those staining in the TUNEL assay. Uninjected fields of cells have low frequencies of cells staining in the TUNEL assay. Hong Zhang et al. Cancer Res 1999;59:3021-3027 ©1999 by American Association for Cancer Research