Signal and systems analyses for discriminating chronotoxicity classes based on selected circadian mRNA gene expressions in liver and colon mucosa. Signal.

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Signal and systems analyses for discriminating chronotoxicity classes based on selected circadian mRNA gene expressions in liver and colon mucosa. Signal and systems analyses for discriminating chronotoxicity classes based on selected circadian mRNA gene expressions in liver and colon mucosa. A, Hinton representation of the loading matrix of the factors according to factor analysis of gene expressions. The display illustrates the importance of each gene expression as a colored rectangle with dimensions being proportional to the absolute values of the corresponding coefficients in the loading matrix (an intensity colored scale ranging from dark blue for lowest value to brown for highest value). B, error degrees of freedom (DFE) and the maximized log likelihood (-log L) as a function of number of components, according to factor analysis. C, results from sparse LDA of gene expression spectra, with most important variables corresponding to largest rectangle size and “warmest” (red) or “coolest” (blue) color. Xiao-Mei Li et al. Cancer Res 2013;73:7176-7188 ©2013 by American Association for Cancer Research