Structure and function of RND efflux pumps in P. aeruginosa.

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Structure and function of RND efflux pumps in P. aeruginosa. Structure and function of RND efflux pumps in P. aeruginosa. RND pumps typically exist in a tripartite system consisting of an RND cytoplasmic membrane transporter (RND), an MFP, and an OMF. This complex forms a channel spanning the entire membrane, allowing for the proton-driven transport of lipophilic and amphiphilic drugs from the cytoplasm of the cell across the cytoplasmic membrane, through the periplasmic space, across the peptidoglycan, and across the outer membrane. The RND efflux pumps can also extrude drugs from the periplasmic space before they cross the cytoplasmic membrane. Philip D. Lister et al. Clin. Microbiol. Rev. 2009; doi:10.1128/CMR.00040-09