David J.A. Jenkins et al. JACC 2018;71:2570-2584 Forest Plot of Folic Acid Supplementation and CVD Risk The diamond represents the pooled risk estimate. Interstudy heterogeneity was tested using the Cochran Q statistic (chi-square) at a significance level of p < 0.10 and quantified by the I2 statistic. The results show a RR of 0.83 in favor of folic acid. This 17% reduction in CVD risk was driven by the highly influential Chinese folic acid supplementation study, made in a community without folic acid fortification, but is the major supplement finding of the last 6 years. NNT for folic acid supplementation and CVD risk is 111. Abbreviations as in Figures 1, 2, and 4. David J.A. Jenkins et al. JACC 2018;71:2570-2584 2018 The Authors