IL1R8 is downmodulated in human lymphoma cell lines.

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Presentation transcript:

IL1R8 is downmodulated in human lymphoma cell lines. IL1R8 is downmodulated in human lymphoma cell lines. A, Real-time PCR analysis of IL1R8 mRNA expression (unpaired Student t test of each line versus normal B cells with Welch correction; mean and SD are indicated; the highest P value is reported) and B, flow-cytometric analysis of IL1R8 protein expression (top, representative histograms; bottom, MFI quantification) in human lymphoma cell lines compared with circulating B (CD19+) cells from 3 to 4 healthy donors (unpaired Student t test of each line versus normal B cells; mean and SD are indicated; the highest P value is reported); 3 to 4 experiments were performed with each cell line. Results are expressed as arbitrary units (A) and as MFI normalized on fluorescence minus one (B, bottom). C, Normalized log intensity of IL1R8 probe (218921_at; GSE43677) in DLBCL versus normal B cells (naïve B cells, germinal center (GC) B cells, post GC B cells, and tonsil samples). D, Normalized log intensity of IL1R8 probe (A_23_P84344; GSE32018) in DLBCL versus FL, MCL, MALT, NMZL, CLL, and lymph node samples. E, Kaplan–Meier survival curve of DLBCL patients (n = 98) with low and high IL1R8 gene expression (218921_at probe) within DLBCL specimens (HR, 2.2; 95% CI, 1.2–3.8; P = 0.006). F, Normalized log intensity of IL-37 probe (218921_at; GSE43677) in DLBCL versus normal B cells (naive B cells, germinal center (GC) B cells, post GC B cells and tonsil samples). G, Normalized log intensity of IL-37 probe (A_23_P84344; GSE32018) in DLBCL vs. FL, MCL, MALT, NMZL, CLL and lymph node samples. Federica Riva et al. Cancer Immunol Res 2019;7:874-885 ©2019 by American Association for Cancer Research