Fig. 3 Characterization of PCNs and PCN-loaded microneedles.

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Presentation transcript:

Fig. 3 Characterization of PCNs and PCN-loaded microneedles. Characterization of PCNs and PCN-loaded microneedles. (A) Schematic illustration of the PCN. HA, hyaluronic acid. (B) Cryo-TEM image of PCN1 (palm oil) below the melting temperature (left) and TEM image of PCN1 above the melting temperature (right). (C) Cryo-TEM image of PCN2 (tridecanoic acid) below the melting temperature (left) and TEM image of PCN2 above the melting temperature (right). (D) Dynamic light scattering size measurement of PCNs at 30° (skin temperature), 40°, and 45°C. (E) Optical image (left) and confocal fluorescence (FL) microscope image (right) of PCM-coated microneedles. Microneedles contain dye-loaded PCNs for imaging. (F) Microneedle dissolution test in PBS before (left) and after (right) the PCM coating. (G) Mechanical strength test of microneedles in their dry and wet states. (H) Confocal microscope image of microneedles penetrating into 4% agarose gel (left) and IR camera image of the thermal actuation on the gel (right). (I) Drug-release profile from microneedles. (J) IR camera images of eight different spatiothermal profiles using the three-channel thermal actuator for multistage drug delivery. (K) Multistage drug-release profile. a.u., arbitrary units. Hyunjae Lee et al. Sci Adv 2017;3:e1601314 Copyright © 2017, The Authors