Histamine release in intact human skin by monocyte chemoattractant factor-1, RANTES, macrophage inflammatory protein-1α, stem cell factor, anti-IgE, and.

Slides:

Advertisements

Similar presentations

Yvan Boutin, PhD, Jacques Hébert, MD

Advertisements

Biologic allergen assay for in vivo test allergens with an in vitro model of the murine type I reaction Andreas Hoffmann, VMD, Stefan Vieths, PhD, Dieter.

In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy Philippe A. Eigenmann, MD,

Kiwi fruit allergy: A new birch pollen–associated food allergy

Evaluation and treatment of allergic fungal sinusitis. II

Glucocorticoids inhibit chemokine generation by human eosinophils

Tan Jinquan, MD, PhD, Henrik H. Jacobi, MD, Chen Jing, MD, Claus M

Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen–specific IgE production by stimulation of IL-12 production in mice Shinji.

The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,

Eosinophil cationic protein and histamine after intestinal challenge in patients with cow's milk intolerance Ulf Bengtsson, MD, PhDa, Tina W. Knutson,

Akos Heinemann, MD, Gunter J. Sturm, MD, Martina Ofner, BSc, Eva M

Kiwi fruit allergy: A new birch pollen–associated food allergy

Evaluation and treatment of allergic fungal sinusitis. II

In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy Philippe A. Eigenmann, MD,

Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug- induced cutaneous eruptions Nikhil Yawalkar, MD, Maithili Shrikhande,

Investigation of the mechanism of alcohol-induced bronchial asthma

Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine Amato de Paulis,

Effects of topical glucocorticoids on in vitro lactoferrin glandular secretion: Comparison between human upper and lower airways Jordi Roca-Ferrer, MSa,

Estrogen enhances immunoglobulin production by human PBMCs

Prostaglandin E2 control of T cell cytokine production is functionally related to the reduced lymphocyte proliferation in atopic dermatitis Sai Chan,

Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma Malgorzata Pierzchalska,

The histamine-cytokine network in allergic inflammation

Β-Adrenergic regulation of the eosinophil respiratory burst as detected by lucigenin- dependent luminescence Nicholas E. Hadjokas, PhD a,b, Joseph J.

Cristiana Stellato, MD, PhDa, Jun Atsuta, MD, PhDb, Carol A

Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages Elena Goleva, PhD, Pia J. Hauk, MD, Clifton.

Socioeconomic status and race as risk factors for cockroach allergen exposure and sensitization in children with asthma Sampson B. Sarpong, MDa, Robert.

Increased sensitivity to bradykinin among African Americans

News & Notes Journal of Allergy and Clinical Immunology

Correlation between alcohol-induced asthma and acetaldehyde dehydrogenase-2 genotype Atsuko Takao, MDa, Terufumi Shimoda, MDa, Shigeru Kohno, MDa, Sadahiro.

Glucocorticoids inhibit chemokine generation by human eosinophils

The immunopharmacology of mild asthma

The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood.

Chemokines induce eosinophil degranulation through CCR-3

Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization Qutayba Hamid, MD, PhD, Editor Journal.

Epithelial cells as regulators of airway inflammation

Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production Henk F. Kauffman, PhD, J.F.Chris.

Possible dual role of anti-idiotypic antibodies in combined passive and active immunotherapy in honeybee sting allergy Yvan Boutin, PhDa, Marie Jobin,

Ganglioside GQ1b enhances Ig production by human PBMCs

News & Notes Journal of Allergy and Clinical Immunology

Occupational allergy caused by urticating hair of Brazilian spider

Adoptively transferred late allergic response is inhibited by IL-4, but not IL-5, antisense oligonucleotide Sophie Molet, PhD, David Ramos-Barbón, MD,

Increased urinary excretion of the prostaglandin D2 metabolite 9α,11β-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced.

Sarbjit S. Saini, MDa, Jennifer J

Histamine and tryptase levels in patients with acute allergic reactions: An emergency department–based study Robert Y. Lin, MDa, Lawrence B. Schwartz,

Fractional analysis of sequential induced sputum samples during sputum induction: Evidence that different lung compartments are sampled at different time.

Expression and function of histamine receptors in human monocyte-derived dendritic cells Marco Idzko, MDa, Andrea la Sala, PhDb, Davide Ferrari, PhDc,

Acquisition and alteration of adhesion molecules during cultured human mast cell differentiation Hiroshi Tachimoto, MD, PhD, Sherry A. Hudson, MSB, Bruce.

Ligation of IgE receptors causes an anaphylactic response and neutrophil infiltration but does not induce eosinophilic inflammation in mice Masayuki.

Peter J. Barnes, DM, DSc, FRCP

Chemokines in seasonal allergic rhinitis

Larry L. Thomas, PhD, Michelle D. Haskell, Emmanuel U

Highly increased levels of IgE antibodies to vaccine components in children with influenza vaccine–associated anaphylaxis Mizuho Nagao, MD, PhD, Takao.

Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils Gilles Devouassoux, MDa, Andrew Saxon,

Glucocorticoids induce basophil apoptosis

13-Hydroxy-linoleic acid induces airway hyperresponsiveness to histamine and methacholine in guinea pigs in vivo Paul A.J. Henricks, PhDa, Ferdi Engels,

Pia J. Hauk, MDa, Qutayba A. Hamid, MD, PhDc, George P

Changes in sputum counts and airway hyperresponsiveness after budesonide: Monitoring anti-inflammatory response on the basis of surrogate markers of airway.

Nedocromil sodium and airway inflammation in vivo and in vitro

Rame A. Taha, MDa, Eleanor M. Minshall, PhDa, Donald Y. M

Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: Effect of topical corticosteroids Pota Christodoulopoulos, BSca,

Local expression of ϵ germline gene transcripts and RNA for the ϵ heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma Sun Ying,

Identification of IL-16 as the lymphocyte chemotactic activity in the bronchoalveolar lavage fluid of histamine-challenged asthmatic patients Margaret.

Stefan Dunzendorfer, MDa, Nicole C

IL-4– and IL-5–positive T lymphocytes, eosinophils, and mast cells in allergen-induced late-phase cutaneous reactions in atopic subjects Luis T. Barata,

Mechanisms of inhibition of IgE synthesis by nedocromil sodium: Nedocromil sodium inhibits deletional switch recombination in human B cells Richard K.S.

Reciprocal regulation of cultured human mast cell cytokine production by IL-4 and IFN-γ Hiroshi Tachimoto, MD, PhDa, Motohiro Ebisawa, MD, PhDa,b, Tomohide.

Thymic stromal lymphopoietin does not activate human basophils

Differences in proliferation of the hematopoietic cell line TF-1 and cytokine production by peripheral blood leukocytes induced by 2 naturally occurring.

News & Notes Journal of Allergy and Clinical Immunology

Diisocyanate antigen–enhanced production of monocyte chemoattractant protein-1, IL- 8, and tumor necrosis factor-α by peripheral mononuclear cells of workers.

Presentation transcript:

Histamine release in intact human skin by monocyte chemoattractant factor-1, RANTES, macrophage inflammatory protein-1α, stem cell factor, anti-IgE, and codeine as determined by an ex vivo skin microdialysis technique Lars J. Petersen, MDa, Klaus Brasso, MDb, Morten Pryds, MDb, Per S. Skov, PhDc Journal of Allergy and Clinical Immunology Volume 98, Issue 4, Pages 790-796 (October 1996) DOI: 10.1016/S0091-6749(96)70128-8 Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Histamine release by serial dilutions of anti-IgE (A), codeine (B), and SCF (C). Increasing concentrations of each compound produced a concentration-dependent release of histamine. Histamine is expressed as net total histamine release (picomoles in 20 minutes). Values are means ± SEM of eight (anti-IgE), seven (codeine), and five (SCF) experiments. Journal of Allergy and Clinical Immunology 1996 98, 790-796DOI: (10.1016/S0091-6749(96)70128-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Kinetics of histamine release by anti-IgE (squares), codeine (circles), and SCF (triangles). For each experiment, peak histamine release in 10 consecutive samples, after intradermal injection of the secretagogue, was found. This value was set as 100%, and histamine concentrations in the remainder samples in that experiment were expressed relatively to that sample. Values are means ± SEM of 21 (anti-IgE), 25 (codeine), and 6 (SCF) experiments (see Methods section). Journal of Allergy and Clinical Immunology 1996 98, 790-796DOI: (10.1016/S0091-6749(96)70128-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 A semi-logarithmic diagram showing peak histamine release in three series of experiments after serial dilutions of MCP-1 (open bars), RANTES (filled bars), and MIP-1α (hatched bars), all compared with vehicle responses and the positive control, anti-IgE (400 U/ml), in that particular series of experiments. Neither MCP-1, nor RANTES, nor MIP-1α released significant amounts of histamine; peak histamine release by chemokines was similar to vehicle responses. In comparison, anti-IgE (400 U/ml) showed a significant peak release of 800 to 1000 nmol/L. Values are means ± SEM of seven (MCP-1) and six (RANTES and MIP-1α) investigations. Journal of Allergy and Clinical Immunology 1996 98, 790-796DOI: (10.1016/S0091-6749(96)70128-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 4 Effect of a brief incubation (10 minutes) with 50 μl of MCP-1 (10-6 mol/L), RANTES (10-6 mol/L), MIP-1α (10-6 mol/L), and SCF (5.4 × 10-10 mol/L) versus incubation with vehicle on total histamine release induced by intradermal injection of 25 μl of anti-IgE (400 U/ml) in human skin. Histamine release after preincubation with vehicle is set as 100%. SCF significantly (p < 0.05) potentiated anti-IgE–induced histamine release by 33%, whereas none of the chemokines modulated anti-IgE–induced histamine release. Values are means ± SEM of eight (MCP-1) and seven (RANTES, MIP-1α, and SCF) experiments. Journal of Allergy and Clinical Immunology 1996 98, 790-796DOI: (10.1016/S0091-6749(96)70128-8) Copyright © 1996 Mosby, Inc. Terms and Conditions