cGAS Dimerization Entangles DNA Recognition

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Presentation transcript:

cGAS Dimerization Entangles DNA Recognition Philip J. Kranzusch, Russell E. Vance Immunity Volume 39, Issue 6, Pages 992-994 (December 2013) DOI: 10.1016/j.immuni.2013.11.012 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 RNA and DNA-Induced Oligomerization of Innate Immune Receptors Analogous to ligand-induced oligomerization within TLR3-dsRNA and AIM2-dsDNA complexes, Li et al. (2013) report new dimerization interactions within the cytosolic DNA-sensor cGAS. cGAS contains two unique DNA-binding sites and requires engagement of both surfaces for full activation. Figure models adapted from PDB entries 3CIY and 3RN2. Immunity 2013 39, 992-994DOI: (10.1016/j.immuni.2013.11.012) Copyright © 2013 Elsevier Inc. Terms and Conditions