Thoracoscopic Versus Thoracotomy Approaches to Lobectomy: Differential Impairment of Cellular Immunity Bryan A. Whitson, MD, PhD, Jonathan D'Cunha, MD,

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Thoracoscopic Versus Thoracotomy Approaches to Lobectomy: Differential Impairment of Cellular Immunity Bryan A. Whitson, MD, PhD, Jonathan D'Cunha, MD, PhD, Rafael S. Andrade, MD, Rosemary F. Kelly, MD, Shawn S. Groth, MD, Baolin Wu, PhD, Jeffrey S. Miller, MD, Robert A. Kratzke, MD, Michael A. Maddaus, MD The Annals of Thoracic Surgery Volume 86, Issue 6, Pages 1735-1744 (December 2008) DOI: 10.1016/j.athoracsur.2008.07.001 Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Flow cytometry analysis of the phenotype of the peripheral blood mononuclear cells perioperatively. (A) Cytotoxic (CD3+/CD8+) and helper (CD3+/CD4+) T-cell subsets. (B) CD4/CD8 ratio. (OT = open thoracotomy; POD = postoperative day; PREOP = preoperatively; VATS = video-assisted thoracoscopic surgery.) The Annals of Thoracic Surgery 2008 86, 1735-1744DOI: (10.1016/j.athoracsur.2008.07.001) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Cellular cytotoxicity. (A) Percent specific lysis. (B) Normalized (to postoperative day [POD] 0) percent specific lysis. (OT = open thoracotomy; PREOP = preoperatively; VATS = video-assisted thoracoscopic surgery.) The Annals of Thoracic Surgery 2008 86, 1735-1744DOI: (10.1016/j.athoracsur.2008.07.001) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Gene signature validation. (RT-PCR = reverse-transcriptase polymerase chain reaction; VATS = video-assisted thoracoscopic surgery.) The Annals of Thoracic Surgery 2008 86, 1735-1744DOI: (10.1016/j.athoracsur.2008.07.001) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Protein validation of gene expression. (A) Matrix metalloproteinase 9 concentrations. (B) Insulin-like growth factor binding protein 3 concentrations. (OT = open thoracotomy; POD = postoperative day; PREOP = preoperatively; VATS = video-assisted thoracoscopic surgery.) The Annals of Thoracic Surgery 2008 86, 1735-1744DOI: (10.1016/j.athoracsur.2008.07.001) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions