A, structure of the deduced polypeptides coded by MAGE-E1 mRNAs.

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A, structure of the deduced polypeptides coded by MAGE-E1 mRNAs. A, structure of the deduced polypeptides coded by MAGE-E1 mRNAs. The deduced polypeptides encoded by MAGE-E1 mRNAs are schematically demonstrated. All of them possess the NH2-terminal 348 amino acids. MAGE-E1b is identical to MAGE-E1a except for 2 amino acids missing in the COOH terminus. MAGE-E1c lacks a large portion of COOH-terminal half and has a distinct 66-amino acid tail. ▪, MAGE-conserved domain. B, homology of deduced MAGE-E1a polypeptides with other MAGEs. Homology search with the database showed that deduced MAGE-E1a polypeptides were highly homologous with other MAGE family members at a region spanning 421–600 amino acids: 78.3% identical to MAGE-D1; 41.1% to MAGE-A1; 43.5% to MAGE-B1; and 41.4% to MAGE-C1. Manabu Sasaki et al. Cancer Res 2001;61:4809-4814 ©2001 by American Association for Cancer Research