Two autopsy cases.A, Axial FLAIR (10,000/156/1) image obtained in a 63-year-old man shows grade 1 signal intensity abnormality in the anterior subependymal region of the splenium.B, Photomicrograph of histologic specimen of the splenium (same patient as in ... Two autopsy cases.A, Axial FLAIR (10,000/156/1) image obtained in a 63-year-old man shows grade 1 signal intensity abnormality in the anterior subependymal region of the splenium.B, Photomicrograph of histologic specimen of the splenium (same patient as in A) demonstrates a band of isomorphic gliosis (hematoxylin and eosin stain; original magnification, x60).C, Axial FLAIR (10,000/156/1) image obtained in an 80-year-old man shows grade 1 signal intensity abnormality in the anterior subependymal region of the splenium.D, Photomicrograph of histologic specimen of the splenium (same patient as in C) shows no gliosis (hematoxylin and eosin stain; original magnification, x60). Joseph S. Pekala et al. AJNR Am J Neuroradiol 2003;24:855-861 ©2003 by American Society of Neuroradiology