MICROENCAPSULATION Asst.Prof . kottam institute of pharmacy, A.P SHUBHRAJIT MANTRY Asst.Prof . kottam institute of pharmacy, A.P

INTRODUCTION polymeric material. Microencapsulation is a process by which very tiny droplets or particles of liquid or solid material are surrounded or coated with a continuous film of polymeric material. The product obtained by this process is called as micro particles, microcapsules. Particles having diameter between 3 - 800µm are known as micro particles or microcapsules or microspheres. Particles larger than 1000µm are known as Macro particles .

CLASSIFICATION OF MICROPARTICLE Generally Micro particles consist of two components a) Core material b) Coat or wall or shell material. 1.Microcapsules: The active agent forms a core surrounded by an inert diffusion barrier. 2.Microspheres: The active agent is dispersed or dissolved in an inert polymer.

ADVANTAGES: To Increase of bioavailability To alter the drug release To improve the patient’s compliance To produce a targeted drug delivery To reduce the reactivity of the core in relation to the outside environment To decrease evaporation rate of the core material. To convert liquid to solid form & To mask the core taste.

FUNDAMENTAL CONSIDERATION: Microencapsulation Core material Coating material Vehicle Solid Liquid Polymers Aqueous Nonaqueous Waxes Resins Proteins Polysaccharides

APPLICATION OF MICROENCAPSULATION TECHNIQUES:

Microencapsulation : Applications Chemistry Printing & recording Carbonless paper, Adhesives Pigments and Fillers Catalysts Medicine & Pharmacy & vetinary Control release, Taste masking Vectorisation Artificial organs single dose treatment Food & feed Aromas, Probiotics Unsaturated oil, Enzyme food processing amino acid for cows Agriculture Fungicide – herbicide, Insect repellent, Biopesticide Pigments and fillers Artificial insemination Biotechnology & environment Continuous reactor, Shear protection, Reactor oxygenation Consumer & diversified Cosmetics, detergents (enzymes), sanitary (active, aromas)

MICROENCAPSULATION TECHNIQUES:

MICROENCAPSULATION TECHNIQUES: Air suspension techniques( Wurster) Coacervation process Spray drying & congealing Pan coating Solvent evaporation Polymerization Extrusion Single & double emulsion techniques Supercritical fluid anti solvent method (SAS) Nozzle vibration technology

Air Suspension Techniques( Wurster) Microencapsulation by air suspension technique consist of the dispersing of solid, particulate core materials in a supporting air stream and the spray coating on the air suspended particles. Within the coating chamber, particles are suspended on an upward moving air stream. The design of the chamber and its operating parameters effect a recalculating flow of the particles through the coating zone portion of the chamber, where a coating material, usually a polymer solution, is spray applied to the moving particles.

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