Effect of coapplication of dexrazoxane and doxorubicin on DSB formation, TOP2A protein level, and apoptosis. Effect of coapplication of dexrazoxane and.

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Effect of coapplication of dexrazoxane and doxorubicin on DSB formation, TOP2A protein level, and apoptosis. Effect of coapplication of dexrazoxane and doxorubicin on DSB formation, TOP2A protein level, and apoptosis. A, DSB, assessed as γ-H2AX foci, and TOP2A protein level following 0.1 or 1 μmol/L doxorubicin and/or 100 μmol/L dexrazoxane administrated for the indicated periods schematically depicted in B, that is for 0.5 h before doxorubicin (0.5 h), for 0.5 h before and subsequently together with doxorubicin (24.5 h), together with doxorubicin (24 h), and during the last 6 h of the incubation with doxorubicin (6 h). *, P < 0.05, compared with cells treated with the same doxorubicin concentration but without dexrazoxane. B, apoptosis detected by Annexin V-FITC staining and FACS analysis in cells treated under the same conditions as in A. *, P < 0.05, compared with cells treated with the same concentration of doxorubicin but without dexrazoxane. Tiandong Yan et al. Mol Cancer Ther 2009;8:1075-1085 ©2009 by American Association for Cancer Research