A glomerulus exhibits mesangiolysis, endothelial denudation, red blood cell congestion, and glomerular basement membrane duplication in this example of thrombotic microangiopathy. A glomerulus exhibits mesangiolysis, endothelial denudation, red blood cell congestion, and glomerular basement membrane duplication in this example of thrombotic microangiopathy. (Jones methenamine silver stain; original magnification, ×600.) Courtesy of Glen S. Markowitz. Mark A. Perazella CJASN 2012;7:1713-1721 ©2012 by American Society of Nephrology