Oxygenated Lipids: A Mode to WiPE Out Inflammation?

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Oxygenated Lipids: A Mode to WiPE Out Inflammation? Amelia E. Hochreiter-Hufford, Kodi S. Ravichandran Immunity Volume 36, Issue 5, Pages 699-701 (May 2012) DOI: 10.1016/j.immuni.2012.05.006 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Sorting Apoptotic Cells for Clearance Resident macrophages express the PS engulfment receptor Tim-4, which provides them recognition of apoptotic cells. MFG-E8 is the bridging molecule linking the phosphatidylserine (PS) exposed on apoptotic cells to integrin receptors on the surface of phagocytes. Inflammatory monocytes require MFG-E8 for recognition of apoptotic cells. Resident macrophages express 12/15-LO, allowing oxidation of phosphatidylethanolamine (oxPE). Resident macrophages are enriched with oxidized PE species, and this oxPE appears to sequester MFG-E8 and thereby interfere with the MFG-E8 dependent recognition of PS by inflammatory monocytes. Immunity 2012 36, 699-701DOI: (10.1016/j.immuni.2012.05.006) Copyright © 2012 Elsevier Inc. Terms and Conditions