Hisato Takagi, MD, PhD, Masafumi Matsui, MD, Takuya Umemoto, MD, PhD

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Off-Pump Coronary Artery Bypass May Increase Late Mortality: A Meta-Analysis of Randomized Trials Hisato Takagi, MD, PhD, Masafumi Matsui, MD, Takuya Umemoto, MD, PhD The Annals of Thoracic Surgery Volume 89, Issue 6, Pages 1881-1888 (June 2010) DOI: 10.1016/j.athoracsur.2010.03.010 Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Quality of reporting of meta-analyses [9] flow diagram for the meta-analysis. (CABG = coronary artery bypass grafting.) The Annals of Thoracic Surgery 2010 89, 1881-1888DOI: (10.1016/j.athoracsur.2010.03.010) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Forest plot (graphic display of findings of systematic reviews and meta-analyses) of late all-cause mortality among patients randomized to off-pump versus on-pump coronary artery bypass grafting. Gray boxes represent risk ratio. The Annals of Thoracic Surgery 2010 89, 1881-1888DOI: (10.1016/j.athoracsur.2010.03.010) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Leave-one-out meta-analysis excluding individual results one at a time and recalculating the pooled risk ratio (gray boxes) estimates for the remaining results. The Annals of Thoracic Surgery 2010 89, 1881-1888DOI: (10.1016/j.athoracsur.2010.03.010) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Meta-regression for duration of follow-up on the logarithm of point estimate (risk ratio). Each result is represented by a circle proportional to its weight in the analysis. The Annals of Thoracic Surgery 2010 89, 1881-1888DOI: (10.1016/j.athoracsur.2010.03.010) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Funnel plot of the logarithm of point estimate (risk ratio) versus the inverse standard error for each result (circles). The Annals of Thoracic Surgery 2010 89, 1881-1888DOI: (10.1016/j.athoracsur.2010.03.010) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions