Fig. 5 Predictions of the efficacy of sickling inhibitors with the kinetic model. Predictions of the efficacy of sickling inhibitors with the kinetic model.

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Fig. 5 Predictions of the efficacy of sickling inhibitors with the kinetic model. Predictions of the efficacy of sickling inhibitors with the kinetic model. (A) Evolution of the fraction of sickled RBCs in the absence of sickling inhibitors. Black line, experimental results reported in (22); red dashed line, the prediction based on the universal curve of delay time versus supersaturation in (22); blue dashed line, prediction of the kinetic model. (B and C) The fraction of sickled RBCs decreases with increased MCV at 60 s after photolysis. The swelling of RBCs is induced by (B) monensin A and (C) gramicidin A. Blue curves represent our simulation results, and black dashed curves denote the experimental results reported in (22). Squares and diamonds denote 4-hour incubations. Triangles denote 24-hour incubations. (D and E) Sickled fractions at 60 after photolysis of SCT RBCs treated with (D) AES103 and (E) GBT440 at a variety of concentrations. Blue curves represent our simulation results, and black curves denote the experimental results reported in (22). Square and diamond symbols denote 4-hour incubations. Triangle symbols denote 24-hour incubations. logarithm bas 10, Log10. Lu Lu et al. Sci Adv 2019;5:eaax3905 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).