LUSH Shapes Up for a Starring Role in Olfaction Lisa Stowers, Darren W. Logan  Cell  Volume 133, Issue 7, Pages 1137-1139 (June 2008) DOI: 10.1016/j.cell.2008.06.010 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Two Mechanisms of Olfactory Signaling in Drosophila (A) Many volatile chemicals appear to directly activate odorant receptors, resulting in depolarization of the sensory neuron. (B) Laughlin et al. (2008) demonstrate that the fly pheromone 11-cis vaccenyl acetate (cVA) does not activate a receptor directly. Instead, cVA is bound by LUSH, resulting in a conformational change in the protein that turns the previously inactive LUSH into an active ligand of the pheromone receptor. Cell 2008 133, 1137-1139DOI: (10.1016/j.cell.2008.06.010) Copyright © 2008 Elsevier Inc. Terms and Conditions