Functional recovery of the native heart after cardiomyoplasty in sheep with heart failure: passive and dynamic effects of volume loading Kazuaki Shirota,

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Date of download: 9/16/2016 Copyright © The American College of Cardiology. All rights reserved. From: Oxygen-Saving Effect of a New Cardiotonic Agent,

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Functional recovery of the native heart after cardiomyoplasty in sheep with heart failure: passive and dynamic effects of volume loading Kazuaki Shirota, MD, Yifei Huang, MD, Osamu Kawaguchi, MD, Takeshi Yuasa, MD, Peter W Brady, FRACS, Yuichi Ueda, MD, Stephen N Hunyor, MD The Annals of Thoracic Surgery Volume 73, Issue 3, Pages 849-854 (March 2002) DOI: 10.1016/S0003-4975(01)03452-X

Fig 1 Changes in left ventricular end-diastolic volume (LVEDV) and stroke work (SW) caused by acute volume loading in three groups of sheep in which heart failure had been established 6 months earlier. (A) Dynamic cardiomyoplasty (n = 6), (B) passive CMP (n = 5) and (C) control heart failure (n = 5). Values before volume loading are shown by squares, whereas circles identify the response to volume loading. (∗p < 0.05, ∗∗p < 0.01, NS = not significant.) The Annals of Thoracic Surgery 2002 73, 849-854DOI: (10.1016/S0003-4975(01)03452-X)

Fig 2 Pressure-volume loop diagram of ventricular contraction. (Ees = end-systolic maximal elastance; ESPVR = end-systolic pressure-volume relationship; PE = potential energy; PVA = pressure-volume area; SW = stroke work of contraction represented by the black colored loop area; Vo = volume-axis intercept of ESPVR.) The Annals of Thoracic Surgery 2002 73, 849-854DOI: (10.1016/S0003-4975(01)03452-X)