Staurosporine induces changes in MMP

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Staurosporine induces changes in MMP Staurosporine induces changes in MMP. A, induction of changes in the ΔΨm by staurosporine in Mel-RM and IgR3 lines. Staurosporine induces changes in MMP. A, induction of changes in the ΔΨm by staurosporine in Mel-RM and IgR3 lines. Cells were treated with staurosporine (1 μm) for indicated time periods. The ΔΨm was measured by uptake of the MitoTracker Red CMXRos using flow cytometry. Data are representative of three individual experiments. B, staurosporine-induced changes in ΔΨm are independent of caspases. Mel-RM (left) and IgR3 (right) cells were treated with z-VAD-fmk (20 μm) 1 h before adding staurosporine (1 μm) for indicated time periods. The ΔΨm was measured as described in A. Columns, mean of three individual experiments; bars, SE. C, staurosporine-induced release of cytochrome c and Smac/DIABLO from mitochondria to the cytosol. Mel-RM and IgR3 cells were treated with staurosporine (1 μm) for 6 h before harvest. Mitochondrial and cytosolic fractions were subjected to Western blot analysis. Data are representative of two individual experiments. Western blot analysis of COX IV levels was included to show relative purity of mitochondrial fractions. Xu Dong Zhang et al. Mol Cancer Ther 2004;3:187-197 ©2004 by American Association for Cancer Research