COX-2, Oct-4, and ALDH-1 expression in the mammary gland.

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Presentation transcript:

COX-2, Oct-4, and ALDH-1 expression in the mammary gland. COX-2, Oct-4, and ALDH-1 expression in the mammary gland. A, representative Western blots of mammary glands from rats treated with vehicle (C1 and C2), tamoxifen (T1 and T2), carcinogen (Ca1 and Ca2), and carcinogen + tamoxifen (CaT1 and CaT2). β-Actin was used as a loading control. B, quantitative analysis of Western blots showing that COX-2, Oct-4, and ALDH-1 levels (y axis, integrated absorbance (IOD) were elevated following carcinogen treatment (CARC) compared with controls (CONT). COX-2 expression was reduced by tamoxifen in the CARC + TAM group. Letters indicate significant differences among the treatment groups. C, cytoplasmic ALDH-1 immunostaining was observed in a few luminal epithelial cells in the mammary gland of CARC animals (arrow). No immunoreactivity was observed in control and TAM animals. Bar, 50 μm. Alison Y. Ting et al. Cancer Prev Res 2008;1:546-553 ©2008 by American Association for Cancer Research