Tuft Cells: A New Flavor in Innate Epithelial Immunity

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Tuft Cells: A New Flavor in Innate Epithelial Immunity Richard K. Grencis, John J. Worthington Trends in Parasitology Volume 32, Issue 8, Pages 583-585 (August 2016) DOI: 10.1016/j.pt.2016.04.016 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Taste Your Parasites. Helminth- or infection-induced molecules are sensed via tuft cells expressing transient receptor potential cation channel, subfamily M, member 5 (TRMP5) and gustducin-α. In response, tuft cells release the alarmin interleukin (IL)-25, which increases type two innate lymphoid cell (ILC2) numbers and their secretion of the cytokine IL-13. In turn IL-13 signals to the pluripotent stem cell niche within the intestinal crypt and promotes the differentiation of tuft cells, possibly by altering Notch signaling. This tuft cell hyperplasia causes a feed-forward loop and concurrent goblet cell hyperplasia, leading to worm expulsion. Trends in Parasitology 2016 32, 583-585DOI: (10.1016/j.pt.2016.04.016) Copyright © 2016 Elsevier Ltd Terms and Conditions