Mass spectrometry identification of biomarker candidates in the prediagnostic plasmas in the Women's Health Initiative cohort. Mass spectrometry identification.

Slides:



Advertisements
Similar presentations
Peptide de novo sequencing Peptide de novo sequencing is the analytical process that derives a peptide’s amino acid sequence from its tandem mass spectrum.
Advertisements

Odds ratios for change in PD from earliest mammogram within levels of earliest PD. No evidence for an interaction of earliest PD and change in PD on breast.
KG-501 suppresses NSCLC/IL-1β CM–induced migration of HUVECs by regulating IL-1β–induced CXC chemokine gene expression in NSCLC cells. KG-501 suppresses.
IL-1β differentially regulates CXCL5 and CXCL8 protein secretion in NHTBE and NSCLC cells. IL-1β differentially regulates CXCL5 and CXCL8 protein secretion.
IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.
25(OH)D and 1,25(OH)2D perfusion treatment effect on cancer-related markers: IF stains illustrating expression levels for Ki-67 (A), cyclin D1 (B), ErbB-2.
by Nelson Leung, Samih H. Nasr, and Sanjeev Sethi
Variability in protein concentration of urine over a 10-d collection from a single healthy volunteer. Variability in protein concentration of urine over.
Quantification of readthrough peptides in the presence of paromomycin
Alignment of H-NS, H-NS2, and StpA amino acid sequences.
A, high resolution MS/MS spectrum (lower panel) of 1435
Effect of supplementation with SeMet or SY on plasma selenium levels in adult men. Effect of supplementation with SeMet or SY on plasma selenium levels.
Correction of translational start site by identification of N-terminal peptide. Correction of translational start site by identification of N-terminal.
N-terminal extension of a gene using peptides mapping upstream to an annotated start site. N-terminal extension of a gene using peptides mapping upstream.
Relative quantification of cis and trans PSP gp10040–42/47–52 variants
Distribution of informative SNPs with LOH (black bars) on each chromosome (rows, oriented p-arm at the bottom and q-arm at the top of each chromosome)
ROC curve for separating advanced stages (advanced BE and EA) versus early stages (BE or BE instability) using total genome-wide LOH [area under the curve.
Localization of putative cholesterol-binding motifs in the homology model of human glucose transporter 1 (GLUT1) protein. Localization of putative cholesterol-binding.
Schematic of AIMS-to-MRM experiment.
Clinically significant precounseling cancer distress modifies counseling method's effect on testing uptake. *, statistically significant difference observed.
Differences in breast cancer risk between the 75th and the 25th percentile of urinary phytoestrogen excretion, by race-ethnic group, Multiethnic Cohort.
QSOX1 is highly expressed in tumor cell lines but is not expressed in adjacent normal cells. QSOX1 is highly expressed in tumor cell lines but is not expressed.
Relationships between plasma NEFA concentrations and BMI in two cohorts. Relationships between plasma NEFA concentrations and BMI in two cohorts. Black.
Detection of neoantigen-specific T cell recognition in cancer.
The B. thetaiotaomicron OMV pellet (OMVp) protein content is different from that of the OM. Three hundred micrograms of each preparation and biological.
BRCA1 promoter methylation detected in the peripheral blood and corresponding tumor. BRCA1 promoter methylation detected in the peripheral blood and corresponding.
The power to detect an OR of 2
Evaluation of top candidate clones for selective killing in bispecific antibody format. Evaluation of top candidate clones for selective killing in bispecific.
Effects of AG on the colon histology score in the acute DSS colitis model. Effects of AG on the colon histology score in the acute DSS colitis model. Ten.
Dietary plant extracts inhibit NF-κB activation in vitro.
Scatterplot and LD map of the genotyped tagging SNPs along the TOX3/LOC region. Scatterplot and LD map of the genotyped tagging SNPs along the TOX3/LOC
Diagnostic performance of dentist clinical impression.
Effects of DPM treatment on tumor volume, tumor mass, and pulmonary metastasis at experimental end point. Effects of DPM treatment on tumor volume, tumor.
Relative risks of colon cancer in prospective cohort studies, comparing the highest with the lowest category of heme iron consumption. Relative risks of.
EPA+DHA supplementation does not alter body composition, body weight, or feed intake. EPA+DHA supplementation does not alter body composition, body weight,
Inhibitory effect of different doses of IP6 on prostate tumor progression in TRAMP mice. Inhibitory effect of different doses of IP6 on prostate tumor.
KIT mutations in GISTs. A, amino acid sequence of KIT exon 11 mutations in clinical GIST biopsies. –, amino acids that are deleted; italicized amino acids,
Multivariate-adjusted breast density means for joint relation of IGF-I with IGFBP-3 in premenopausal women. Multivariate-adjusted breast density means.
Correlation between serum visfatin concentrations and the clinical stage (A) and tumor size (B, C) of HCCs. A and B, the correlations were determined by.
Risk (aOR) of breast cancer associated with the combination of putative at-risk genotypes of the MRN genes and the reproductive risk factors of a history.
Age-adjusted breast cancer incidence rates in females by age-adjusted HD incidence rates in females 15–34 years of age in 135 populations in the world.
Peptide dose-response curves were done to estimate the avidity of these HTL for peptide TARP1-14 (A) and TARP14-27 (B-E) using autologous PBMCs and dendritic.
The truncating mutation c
Parity explains the age-associated increase in ANA prevalence in women ages 12 to 59 years, but not in those ages 60+. Parity explains the age-associated.
HCCs with overexpression of biliary/progenitor marker genes.
Differential methylation at 12 selected HPV16 CpGs in cervical cells from premalignant lesions with biopsy-confirmed diagnoses from our original study.
T-cell activation and induction of apoptosis in epithelial cells of oral lesions induced by 4-NQO. T-cell activation and induction of apoptosis in epithelial.
Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. Endogenously produced n-3 PUFAs inhibit endometrial cancer.
Categories of system-based chronic and late medical and neuropsychologic health events graded in the SJLIFE study. Categories of system-based chronic and.
Structures of wild-type and mutated recombinant CDX2.
The percentage of positive among all women (A), women with CIN2, or more severe diagnosis (CIN2+; sensitivity; B), and grade 3 (CIN3) or more severe diagnosis.
HMQ1611 inhibited breast tumor growth in mice.
Scatter plot of serum OPN levels and its correlation with patient survival. Scatter plot of serum OPN levels and its correlation with patient survival.
Location of the ER mutations and frequencies per cohort.
Mean weight change from original weight of (a) BALB/c (b) DBA/2 mice after one (♦) or two (▴) injections of 10 mg/kg and one (▪) or two (×) injections.
The effect of a DIO regimen ± EPA+DHA supplementation on tumor growth.
GATA-3 immunostaining was scored semiquantitatively; tumors with
Progastrin staining in colon adenomas and adenocarcinomas.
A, Proportion for different in silico predictions at the RNA level.
The pattern of association between all-cancer mortality risk and long-term exposure to PM2.5 (μg/m3). The pattern of association between all-cancer mortality.
Individuals affected with cancer included in the Lynch syndrome are colored. Individuals affected with cancer included in the Lynch syndrome are colored.
A, Schematic diagram of identified splice variants of PD-L1.
Quantile–quantile plots of 42 interaction P values for seven SNPs under investigation. Quantile–quantile plots of 42 interaction P values for seven SNPs.
Pooled effect of exercise on glucose, IR, IGF1, and IGFBP3 in breast cancer survivors. Pooled effect of exercise on glucose, IR, IGF1, and IGFBP3 in breast.
Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.
Sequence alignment of colicin lysis proteins.
Quantification of biomarker candidates in prediagnostic plasmas from mouse models of colorectal cancer. Quantification of biomarker candidates in prediagnostic.
The Kras Mutational Spectra of Chemically Induced Lung Tumors in Different Inbred Mice Mimics the Spectra of KRAS Mutations in Adenocarcinomas in Smokers.
CONSORT diagram. a, 5 had a major treatment violation (3 refused and 2 received wrong treatment) but were included in the analyses; b, 4 had a major treatment.
Waterfall plots in 82 ipilimumab-refractory patients receiving nivolumab (3 mg/kg) with (n = 14) or without (n = 82) a peptide vaccine. Waterfall plots.
Presentation transcript:

Mass spectrometry identification of biomarker candidates in the prediagnostic plasmas in the Women's Health Initiative cohort. Mass spectrometry identification of biomarker candidates in the prediagnostic plasmas in the Women's Health Initiative cohort. Schema of three biomarker candidates (AK1, CLIC1, and SOD1) and identification of peptides by mass spectrometry. Gray bars indicate identified peptides. Numbers indicate mass spectra counts for each peptide, and numbers in parentheses indicate mass spectra counts with quantification. The amino acid sequence is based on P00568-1 for AK1, O00299-1 for CLIC1, and P00441-1 for SOD1 in the UniProt Knowledgebase. Ayumu Taguchi et al. Cancer Prev Res 2015;8:1112-1119 ©2015 by American Association for Cancer Research