Dysfunctional HDL Takes Its Toll in Chronic Kidney Disease

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Dysfunctional HDL Takes Its Toll in Chronic Kidney Disease Kathryn J. Moore, Edward A. Fisher Immunity Volume 38, Issue 4, Pages 628-630 (April 2013) DOI: 10.1016/j.immuni.2013.03.006 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Elevated SDMA in Chronic Kidney Disease Generates Dysfunctional HDL In CKD, SDMA accumulates in HDL, rendering this normally protective lipoprotein dysfunctional. SDMA-HDL or HDLCKD initiates TLR2 signaling on endothelial cells that results in increased superoxide production and reduced NO bioavailability and, consequently, increased blood pressure. Immunity 2013 38, 628-630DOI: (10.1016/j.immuni.2013.03.006) Copyright © 2013 Elsevier Inc. Terms and Conditions