Abnormal monocyte distribution and loss of HLA-DR in patients with stage IV melanoma. Abnormal monocyte distribution and loss of HLA-DR in patients with.

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Abnormal monocyte distribution and loss of HLA-DR in patients with stage IV melanoma. Abnormal monocyte distribution and loss of HLA-DR in patients with stage IV melanoma. Peripheral blood was analyzed by flow cytometry. A, frequency of monocytes as measured by forward scatter and side scatter in the leukocyte population of patients with malignant melanoma (MMP) and healthy volunteer controls (HV). B, frequency of CD14+CD16− classical, CD14+CD16+ intermediate, CD14loCD16+ nonclassical monocytes subsets as a percentage of the monocytes pool in both healthy volunteers and malignant melanoma patients. C, frequency of CD14+HLA-DRlow/− % of monocytes as a percentage of CD14+ monocytes. D, HLA-DR expression as measured by mean fluorescence intensity (MFI) on the monocyte subsets. Box and whisker plots: horizontal line, median; box, 25th and 75th percentiles; whiskers, min and max; **, P < 0.01. Rahul Chavan et al. Cancer Immunol Res 2014;2:241-248 ©2014 by American Association for Cancer Research