Cellular players and molecules in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease. Cellular players and.

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Presentation transcript:

Cellular players and molecules in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease. Cellular players and molecules in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease. Cells inside dashed lines are relevant to IPF pathogenesis only. ROS: reactive oxygen species; TGF: transforming growth factor; IL: interleukin; MCP: monocyte chemotactic protein; PDGF: platelet-derived growth factor; ET: endothelin; PMNC: peripheral blood mononuclear cell; EMT: epithelial–mesenchymal transition; CTGF: connective tissue growth factor; Th2: T-helper cell type 2; AEC: alveolar epithelial cell; PMC: pleural mesothelial cell. Gianluca Bagnato, and Sergio Harari Eur Respir Rev 2015;24:102-114 ©2015 by European Respiratory Society