RT-TEX induce activation and IFN-I production by primary DCs

Slides:

Advertisements

Similar presentations

Glioma-derived soluble factor(s) enhance IL-10 signaling.

Advertisements

NK cells inhibited the expansion and function of ILC2s in vitro via IFN-γ. NK cells inhibited the expansion and function of ILC2s in vitro via IFN-γ. ILC2s.

Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation by Juliette Mouriès, Gabriel Moron, Géraldine Schlecht,

IFN-γ and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4+ but not CD8+ T cells by Joseph Barbi, Steve Oghumu, Claudio.

Melanoma donor (MD) NK cells are functionally impaired/exhausted.

IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses by Ruth A. Ettinger,

Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease by Tomomi Toubai, Yaping Sun, Isao Tawara, Ann Friedman,

Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells by Elke Scandella, Ying Men, Silke Gillessen,

by Éric Aubin, Réal Lemieux, and Renée Bazin

Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand Junyan Han, PhD, Azzeddine.

Expression and regulation of MD-2s.

Fig. 1 pDCs infiltrate the skin of SSc patients and spontaneously secrete IFN-α and CXCL4. pDCs infiltrate the skin of SSc patients and spontaneously secrete.

Human dendritic cell subset 4 (DC4) correlates to a subset of CD14dim/−CD16++ monocytes Federica Calzetti, BS, Nicola Tamassia, PhD, Alessandra Micheletti,

H31m1-PDL1 cells form progressively growing tumors in WT mice.

Fig. 3 TLR8 signaling induces CXCL4 and IFN-α secretion by SSc PDCs.

IL-6 is dispensable for the suppressive activity of MDSC on primary CD4+ T-cell activation. IL-6 is dispensable for the suppressive activity of MDSC on.

Cetuximab treatment increases IFNγ receptor 1 expression.

TIGIT expression in naive T cells is accelerated by coculture with si-tolerant T cells at an early-stimulation stage. TIGIT expression in naive T cells.

Volume 29, Issue 2, Pages (August 2008)

Volume 137, Issue 5, Pages (November 2009)

Increased chemokine content and leukocyte infiltrate in D6-negative tumors. Increased chemokine content and leukocyte infiltrate in D6-negative tumors.

Microarray analysis of phospho-Twist1–responsive genes.

Dysfunctional antifungal neutrophils have impaired expression of IFN-inducible genes. Dysfunctional antifungal neutrophils have impaired expression of.

Fig. 2. Circulating VEGF in GCA patients up-regulates microvascular endothelial Jagged1. Circulating VEGF in GCA patients up-regulates microvascular endothelial.

Response of monocytes to hY4 delivery and cytokine levels in CLL serum

Correlation of mouse gene expression with bacterial gene expression.

CCR2+ monocytes are a relevant source of type I IFN in response to Af.

TLR9 deficiency promotes aberrant T cell and myeloid dendritic cell (DC) phenotype in imiquimod-induced autoimmunity. TLR9 deficiency promotes aberrant.

2aG4 directly induces monocytic MDSCs to differentiate into dendritic cells and macrophages by binding to phosphatidylserine on their cell surface. 2aG4.

Human cells produce type I and III IFNs upon Af stimulation.

The mucosal environment regulates CD160 expression on IELs

AhR activation reduces lung DC gene and surface expression of DC-SIGN.

PD-1 blockade enhances T-cell function.

Duy Pham, PhD, Sarita Sehra, PhD, Xin Sun, PhD, Mark H. Kaplan, PhD

M-MDSC:mast cell cross-talk in the regulation of TNFα production.

Induction of CDCP1 is regulated by Ras in NSCLC cells.

PD-L1 expression by DC subsets from lesional CTCL and healthy skin.

Impaired Interferon-Alpha Production by Plasmacytoid Dendritic Cells after Cord Blood Transplantation in Children: Implication for Post-transplantation.

BLITC reporter for monitoring of GvHD.

Kinetic of NFAT-CBR expression.

pDCs from the melanoma environment responded to TLR-L stimulation.

DAC treatment activates expression of immunoregulatory genes.

Direct recognition of MHC II/TARP14-27 on tumor cells by HTL

SAF-1 expression in clinical breast cancer tissues.

The AKT–mTOR pathway controls PD-L1 protein expression.

Uptake of TEX by DCs in vivo.

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8 by Marie Dominique Ah Kioon, Claudio Tripodo, David Fernandez, Kyriakos.

Radiation does not alter AKT and MTOR gene expression.

Dysregulated NF-κB activation in Il1r8+/+/lpr and Il1r8−/−/lpr mice.

Expression of lnc-C/EBPβ in inflammation and in MDSCs induced by tumor-associated factors. Expression of lnc-C/EBPβ in inflammation and in MDSCs induced.

Neurotensin and insulin induce increases in CTGF, CYR61, and CXCL5 gene expression and stimulate cell proliferation and colony via YAP/TAZ in PDAC cells.

Isolation and proteomic profiling of TEX

Effect of nivolumab or ipilimumab on immune responses to vaccination in cynomolgus monkeys. Effect of nivolumab or ipilimumab on immune responses to vaccination.

Reconstitution of the wild-type CD11b+Ly6G+ myeloid cell subset in Tgfbr2MyeKO mice reversed the diminished metastasis phenotype. Reconstitution of the.

Trametinib and combination promote moDC maturation and decrease moDC viability. Trametinib and combination promote moDC maturation and decrease moDC viability.

Role of NO and IFNγ in mast cell–dependent MDSC-suppressive activities

Monocytes from melanoma patients are unresponsive to TLR3 agonists.

Decreased dopamine uptake following downregulation of SLC6A3.

Immune checkpoint molecule expression in primary and secondary tumors following radiotherapy. Immune checkpoint molecule expression in primary and secondary.

CpG oligodeoxynucleotide (CpG ODN)–induced activation of different types of primary malignant B cells. CpG oligodeoxynucleotide (CpG ODN)–induced activation.

Release of IL1RA in response to DNA damage does not depend on de novo translation or classical secretory pathways. Release of IL1RA in response to DNA.

LDL cholesterol inhibits Vγ9Vδ2 T-cell activation and cytokine production. LDL cholesterol inhibits Vγ9Vδ2 T-cell activation and cytokine production. Preexpanded.

Expression of chemokine receptors in A-498 cell line.

Increased tumorigenic activities of TIM-3–expressing RCC cells.

Human melanoma induces paracrine β-catenin signaling activation in DCs in vitro. Human melanoma induces paracrine β-catenin signaling activation in DCs.

EC-derived SP cells are targeted by CD30.CAR T cells.

Bioinformatic analyses suggest that PI3K/AKT signaling may be a key downstream pathway of tazarotene signaling. Bioinformatic analyses suggest that PI3K/AKT.

Fig. 4 Rotavirus induces the type I IFN pathway and release of ATP by tumor cells. Rotavirus induces the type I IFN pathway and release of ATP by tumor.

Surface expression of chemokine receptors on M

Presentation transcript:

RT-TEX induce activation and IFN-I production by primary DCs RT-TEX induce activation and IFN-I production by primary DCs. 1 × 106 CD11c+ DCs isolated from spleens were cultured for 48 hours with TEX (30 μg) or TLR3 agonist poly:ICLC (0.025 mg/mL) and analyzed for (A and B) expression of costimulatory molecules and (... RT-TEX induce activation and IFN-I production by primary DCs. 1 × 106 CD11c+ DCs isolated from spleens were cultured for 48 hours with TEX (30 μg) or TLR3 agonist poly:ICLC (0.025 mg/mL) and analyzed for (A and B) expression of costimulatory molecules and (C and D) IFN-I pathway activation. A, Histograms showing costimulatory molecule expression on DCs cultured with PBS (CTRL: shaded gray), UT-TEX (gray line), RT-TEX (black line), and poly:ICLC (black broken line). B, Mean fluorescence intensity (MFI) ± SEM of samples in each group (n = 3/group). MFI was calculated after subtracting background. C, Gene expression evaluated by qRT-PCR. D, IFNβ measured by ELISA in the supernatant of DCs. Results are representative of two independent experiments. Using a Student two-tailed t test; *, P < 0.05; **, P < 0.005; ***, P < 0.0005; ****, P < 0.00005. Julie M. Diamond et al. Cancer Immunol Res 2018;6:910-920 ©2018 by American Association for Cancer Research