Fig. 3 Mmp-2−/− mice are protected from obesity and leptin resistance.

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Fibroblast activation in WT and NFATc2-deficient mice.

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Fig. 3 Mmp-2−/− mice are protected from obesity and leptin resistance. Mmp-2−/− mice are protected from obesity and leptin resistance. (A) Body weight in WT and Mmp-2−/− mice fed a HFD (n = 8). (B) Weight gain in WT and Mmp-2−/− mice after HFD intake (means ± SD; *P < 0.05, n = 8). (C) Representative WB for the detection of active Mmp-2 in brain homogenate of mice fed a CD or a HFD. (D) Concentrations of Mmp-2 were quantified and are presented as RDU ± SD normalized against actin. *P < 0.05, CD versus HFD. (E) Representative WB of the ObR extracellular domain in Mmp-2−/− mice fed a HFD, WT mice fed a CD, and WT mice fed a HFD. (F) The density of the bands was determined relative to β-actin, and results are presented as RDU ± SD. *P < 0.05, WT (HFD) versus Mmp-2−/− (HFD); **P < 0.05, WT (HFD) versus WT (CD); n = 8. (G) Immunolabeling using an antibody against the extracellular domain of the ObR in the hypothalamus of WT mice fed a HFD, WT mice fed a CD, and Mmp-2−/− mice fed a HFD. White arrows point to ObR staining. Scale bar, 20 μm. (H) Serum leptin concentrations measured with enzyme-linked immunosorbent assay after HFD (WT and Mmp-2−/−) and CD intake (WT) [*P < 0.001, WT (HFD) versus WT (CD); **P < 0.001, WT (HFD) versus Mmp-2−/− (HFD); n = 9 per group]. Rafi Mazor et al., Sci Transl Med 2018;10:eaah6324 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works