Malignant neoplasms of the mouse lung.

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Malignant neoplasms of the mouse lung. Malignant neoplasms of the mouse lung. A, keratinizing squamous cell carcinoma induced by topical cutaneous administration of N-nitroso-tris-chloroethylurea. Boston lung workshop reference set number (LW) 070. B, higher magnification reveals that squamous differentiation is manifested by formation of keratin pearls (arrow) and dyscohesion of keratinizing cells (arrowhead). C, spontaneous papillary adenocarcinoma developed in a 25-month-old 129S4/SvJae mouse. LW003. In addition to papillary area with bronchiolar invasion (arrow), there is a less-differentiated area containing vacuolated tumor cells (arrowhead). D, higher magnification of the same section. Cells lining papillary stalks have vesicular nuclei with prominent multiple nucleoli. Mitoses are frequent (arrow). E, adenocarcinoma, not otherwise specified (NOS) in mouse with triple genetic modification (transgenes Tet-op-K-Ras4bG12D and CCSP-rtTA and targeted mutation p53−/−) 1 month after conditional activation of mutant K-rasby doxycycline administration. The neoplastic cells infiltrate alveolar septae and form aggregates in the alveolar lumen with presence of multinucleated bizarre cells (arrow). LW049. F, neuroendocrine carcinoma induced by recombinant adenovirus carrying Cre recombinase (AdCre)-mediated conditional inactivation of p53 and Rb1. LW011. Densely packed tumor cells with scant cytoplasm and finely granular chromatin form nests (arrow) with a fine vascular stroma. H & E, ScanScope images. Calibration bar: A, 200 μm; B, D, E, and F, 100 μm; C, 400 μm. Alexander Yu. Nikitin et al. Cancer Res 2004;64:2307-2316 ©2004 by American Association for Cancer Research