RET Rearrangements in Lung Adenocarcinoma and Radiation

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Presentation transcript:

RET Rearrangements in Lung Adenocarcinoma and Radiation Sanja Dacic, MD, PhD, Alyssa Luvison, BS, Viktoria Evdokimova, PhD, Lindsey Kelly, BS, Jill M. Siegfried, PhD, Liza C. Villaruz, MD, Mark A. Socinski, MD, Yuri E. Nikiforov, MD, PhD Journal of Thoracic Oncology Volume 9, Issue 1, Pages 118-120 (January 2014) DOI: 10.1097/JTO.0000000000000015 Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 KIF5B/RET rearrangement in the adenocarcinoma cells from a patient with a history of radiation therapy for breast cancer. Normal cells without rearrangement show two red and two green signals separated, whereas cells with rearrangement show one red and one green signal separated and one pair of red and green signals in juxtaposition. Journal of Thoracic Oncology 2014 9, 118-120DOI: (10.1097/JTO.0000000000000015) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 A, Generation of DSBs was monitored by formation of γH2AX nuclear foci. B, Induction of KIF5B/RET, but not CCDC6/RET or NCOA4/RET rearrangements in 201T lung cells by γ radiation. Journal of Thoracic Oncology 2014 9, 118-120DOI: (10.1097/JTO.0000000000000015) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions