Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency Paul J. Maglione, MD,

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Presentation transcript:

Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency Paul J. Maglione, MD, PhD, Huaibin M. Ko, MD, Mary B. Beasley, MD, James A. Strauchen, MD, Charlotte Cunningham-Rundles, MD, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 2, Pages 535-542 (February 2014) DOI: 10.1016/j.jaci.2013.08.022 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The B-cell/T-cell ratio is variable in patients with CVID-associated PLH. A, Immunohistochemical staining of lungs for 2 representative patients demonstrating that the B-cell/T-cell ratio is variable among patients with CVID-associated PLH (original magnification ×40). B, Flow cytometric analysis of lungs from a representative patient with CVID-associated PLH. Journal of Allergy and Clinical Immunology 2014 133, 535-542DOI: (10.1016/j.jaci.2013.08.022) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Pulmonary lymphocytes are organized into B- and T-cell zones in patients with CVID-associated PLH. Hematoxylin-eosin and immunohistochemical staining for CD3 (T cells) and CD20 (B cells) is shown for 5 patients. Areas of B- and T-cell predominance are labeled as B and T, respectively. Magnification of images is ×40. Journal of Allergy and Clinical Immunology 2014 133, 535-542DOI: (10.1016/j.jaci.2013.08.022) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Ectopic follicles and germinal centers with localized proliferation in patients with CVID-associated PLH. Magnification is ×100 in patient 1, ×40 in patient 4, and ×200 in patient 5. Journal of Allergy and Clinical Immunology 2014 133, 535-542DOI: (10.1016/j.jaci.2013.08.022) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 CT scan of the chest of patient 1 before and 2 months after rituximab treatment. The CT scan demonstrated significant interval improvement after rituximab treatment, with resolution of ground-glass and solid opacities, as well as hilar and mediastinal adenopathy, with few persistent scattered nodules that were stable or smaller than those in the prior study. Journal of Allergy and Clinical Immunology 2014 133, 535-542DOI: (10.1016/j.jaci.2013.08.022) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions