Effect of nivolumab or ipilimumab on immune responses to vaccination in cynomolgus monkeys. Effect of nivolumab or ipilimumab on immune responses to vaccination.

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Effect of nivolumab or ipilimumab on immune responses to vaccination in cynomolgus monkeys. Effect of nivolumab or ipilimumab on immune responses to vaccination in cynomolgus monkeys. A, humoral immune responses to a particulate HBsAg vaccine by ELISA. Plasma samples obtained at the indicated times were analyzed for anti-HBsAg Abs. B, antibody responses to an SK-MEL-3 vaccine as assessed by flow cytometry. Vaccine-specific antibody responses were measured by incubation of SK-MEL-3 cells with plasma collected at 2-week intervals. Data points represent the mean ± SEM of the mean fluorescence intensity (MFI) values in each treatment group at each collection time point. C, antibody responses to HLA-A2404 were determined from plasma by ELISA. Data points represent the mean ± SEM of the mean OD values in each treatment group. All samples were analyzed at least two times with similar results. Changyu Wang et al. Cancer Immunol Res 2014;2:846-856 ©2014 by American Association for Cancer Research