Tensins: A New Switch in Cell Migration

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Tensins: A New Switch in Cell Migration Ghassan Mouneimne, Joan S. Brugge Developmental Cell Volume 13, Issue 3, Pages 317-319 (September 2007) DOI: 10.1016/j.devcel.2007.08.010 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Model for Alterations in Migration Induced by Tension Isoform Switch (A and B, left panels) In stationary MCF-10A cells, tensin and other adaptor proteins link β1 integrin to actin microfilament bundles (stress fibers) to form focal adhesions. (A and B, right panels) Tensin-switch induced by EGF causes the dissolution of stress fibers, a decrease in focal adhesions, and scattering of MCF10A cells. Cten competes with tensin 3 and other proteins for the binding to β1 integrin tail, uncoupling actin microfilaments from a large percentage of β1. Developmental Cell 2007 13, 317-319DOI: (10.1016/j.devcel.2007.08.010) Copyright © 2007 Elsevier Inc. Terms and Conditions