Intratumoral lymphoid aggregates are sites of postvaccination T-cell activation and regulation. Intratumoral lymphoid aggregates are sites of postvaccination.

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Intratumoral lymphoid aggregates are sites of postvaccination T-cell activation and regulation. Intratumoral lymphoid aggregates are sites of postvaccination T-cell activation and regulation. A, IHC analysis of CD3-, CD20-, CD45RO-, and CD45RA-expressing cells. B, IHC analysis of CD4-, T-bet-, Foxp3-, CXCR3-, CD69-, and granzyme B–expressing cells. C, IHC analysis of B7-H1/PD-L1- and PD-1–expressing cells. D, PD-L1 expression in a representative intratumoral lymphoid aggregate from a vaccinated patient. The square indicates the edge of the intratumoral lymphoid aggregate that is shown in the bottom at a higher magnification. Brown staining indicates expression of the indicated markers. E, absence of PD-L1 expression in a representative PDAC specimen from an unvaccinated patient. Eric R. Lutz et al. Cancer Immunol Res 2014;2:616-631 ©2014 by American Association for Cancer Research