Effect of local IL-6 immunoneutralization on reversal learning performance. a, c, Representative images of cannula placement and injection sites in the.

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Effect of local IL-6 immunoneutralization on reversal learning performance. a, c, Representative images of cannula placement and injection sites in the OFC and dorsal striatum, respectively. *Injection site. b, Injection of the anti-IL-6 antibody into the O... Effect of local IL-6 immunoneutralization on reversal learning performance. a, c, Representative images of cannula placement and injection sites in the OFC and dorsal striatum, respectively. *Injection site. b, Injection of the anti-IL-6 antibody into the OFC increased trials to meet criterion on the reversal learning stage of the attentional set-shifting test compared with the IgG control group. *p < 0.05, compared with IgG control group. d, Injection of the anti-IL-6 antibody into the dorsal striatum had no effect on reversal learning performance. n.s., Not significantly different from IgG control; Cg, cingulate cortex; Fr, frontal cortex; Pir, piriform cortex; CC, corpus collosum; CPu, caudate–putamen; Acb, nucleus accumbens. n = 6 or 7 per group. Jennifer J. Donegan et al. J. Neurosci. 2014;34:953-962 ©2014 by Society for Neuroscience