Bim expression and activation correlates with reduced Notch3 expression and increased anoikis. Bim expression and activation correlates with reduced Notch3.

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Bim expression and activation correlates with reduced Notch3 expression and increased anoikis. Bim expression and activation correlates with reduced Notch3 expression and increased anoikis. A, IGROV-1 cells treated with Notch3 siRNA have increased Bim EL expression compared with control counterparts. B, siNotch3 cells express similar levels of pro-survival proteins. C, siNotch3 cells in non-adherent conditions express more Bim than siNotch3 cells in adherent conditions or siCtrl cells in adherent or non-adherent conditions. D, Bim mRNA expression does not change with Notch3 reduction. Caitlin W. Brown et al. Mol Cancer Res 2015;13:78-85 ©2015 by American Association for Cancer Research