Fig. 5 In vivo gene delivery by the T4-AAV nanoparticles.

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Fig. 5 In vivo gene delivery by the T4-AAV nanoparticles. In vivo gene delivery by the T4-AAV nanoparticles. (A) Luciferase signal dynamics at the site of injection of mice. The bioluminescence scale is provided on the right of the panel and ranges from the most intense (red) to the least intense (blue) on the basis of the radiance intensity. (B) The luminescence signal intensities of PBS, T4(ITRs-Luci), T4(ITRs-Luci)-Soc-AAV(GFP), and T4(ITRs-Luci)-Hoc-AAV(GFP) were quantified as photons per second per centimeter squared per steradian (p s−1 cm−2 sr−1). The values represent means ± SD of three independent replicates. *P < 0.05 and **P < 0.01 compared with T4(ITRs-Luci) alone. Statistical significance was determined using two-tailed Student’s t tests. Jingen Zhu et al. Sci Adv 2019;5:eaax0064 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).