BAF57 is highly expressed in human prostate cancer specimens.

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BAF57 is highly expressed in human prostate cancer specimens. BAF57 is highly expressed in human prostate cancer specimens. A, immunoblotting was performed for BAF57 and lamin B (loading control) in the LNCaP, LAPC4, 22Rv1, DU-145, and PC-3 prostate cancer cells. BT549 cells were used as the negative control. B, nonneoplastic (left) and primary (right) human prostate cancer (PCa) specimens were analyzed by immunohistochemistry for BAF57 using the generated antisera (BAF57, 1:2,000 dilution). C, independent lymph node (LN) metastases of prostate cancer were stained by standard H&E (left) and immunostained for AR (middle) or BAF57 (right). D, immunohistochemical (IHC) staining was performed for BAF57 on a TMA slide containing ∼80 cores. n, number for each category. BAF57 immunohistochemical score is displayed as a composite of intensity + extent of tumor staining as indicated in Materials and Methods. X axis, Gleason scores. M, lymph node metastatic samples. Kevin A. Link et al. Cancer Res 2008;68:4551-4558 ©2008 by American Association for Cancer Research