by Peter Bacchetti, Steven G. Deeks, and Joseph M. McCune

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Presentation transcript:

by Peter Bacchetti, Steven G. Deeks, and Joseph M. McCune Breaking Free of Sample Size Dogma to Perform Innovative Translational Research by Peter Bacchetti, Steven G. Deeks, and Joseph M. McCune Sci Transl Med Volume 3(87):87ps24-87ps24 June 15, 2011 Copyright © 2011, American Association for the Advancement of Science

Fig. 1. How sample size influences the scientific or practical value that a study can be expected to produce, under three different scenarios. How sample size influences the scientific or practical value that a study can be expected to produce, under three different scenarios. Numeric labels on the axes are absent because specific values will differ for different studies, but the qualitative relationship illustrated applies to all studies of new ideas. When the idea is a fundamental breakthrough, this will usually be apparent from a relatively small study. A much larger sample size does not produce much additional value. Similarly, when the idea is completely off-target, this will usually be apparent from a relatively small study. In intermediate cases, larger sample sizes might add value. However, increasing sample size still produces diminishing marginal returns. Peter Bacchetti et al., Sci Transl Med 2011;3:87ps24 Copyright © 2011, American Association for the Advancement of Science