Analysis of A-to-I RNA edits found in transcriptome-wide RNA-seq

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Fig. 3 Analysis of A-to-I RNA edits found in transcriptome-wide RNA-seq. Analysis of A-to-I RNA edits found in transcriptome-wide RNA-seq. (A) Classification of the position in which an A-to-I RNA edit was found. “Five-kilobase downstream” refers to mutations that occur within 5-kb downstream of a coding gene, and “5-kb upstream” refers to mutations that occur within the region 5-kb upstream of a coding gene. (B) For edits in protein coding regions of mRNAs, edits were classified into synonymous or nonsynonymous mutations. (C) For nonsynonymous A-to-I edits in protein-coding regions of RNA, SIFT was used to predict the effect on protein function for these edits. High- or low-confidence calls (indicated in parentheses in the figure) were made according to the standard parameters of the prediction software (see Materials and Methods). Holly A. Rees et al. Sci Adv 2019;5:eaax5717 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).