The Tribble with APL: A New Road to Therapy

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Presentation transcript:

The Tribble with APL: A New Road to Therapy Ruaidhrí Carmody, Karen Keeshan Cancer Cell Volume 31, Issue 5, Pages 612-613 (May 2017) DOI: 10.1016/j.ccell.2017.04.011 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 TRIB3 Stabilizes PML-RARα to Promote Drug Resistance in APL TRIB3 binds to PML-RARα and PML to inhibit all-trans retinoic acid (ATRA) and As2O3-induced SUMOylation(s), ubiquitination(s), and proteasomal degradation of PML-RARα. Depletion of TRIB3 or inhibition of TRIB3 and PML-RARα interaction results in the re-formation of PML nuclear bodies, p53-dependent senescence, and differentiation of APL cells. Cancer Cell 2017 31, 612-613DOI: (10.1016/j.ccell.2017.04.011) Copyright © 2017 Elsevier Inc. Terms and Conditions